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University of Iowa News Release

Sept. 12, 2005

UI Hospitals And Clinics To Study Flu Vaccine

Researchers at University of Iowa Hospitals and Clinics are enrolling participants, ages 18 to 64, in a study evaluating the potential for using lower doses of influenza vaccine to protect people from the flu.

The study will compare the immune responses and reactions of participants given one of four different doses of influenza vaccine. Three different dilutions of influenza vaccine will be given under the skin and will be compared to the standard influenza vaccine that is given intramuscularly.

Patricia Winokur, M.D., UI associate professor of internal medicine, will serve as the principal investigator for the UI portion of the trial. The study is sponsored by the National Institutes of Health and will include nine other study sites.

Inactivated influenza vaccines have been available in the United States for more than 50 years. Routine yearly administration of influenza vaccine has been recommended for adults over age 50, those with chronic diseases and, more recently, children ages 6 months to 2 years old.

In 2004, nearly half of the supply of influenza vaccine in the United States was lost when one of two manufacturers of flu vaccine licensed by the Food and Drug Administration had to withdraw its product due to safety concerns. This event highlighted the need for developing ways to expand influenza vaccine supplies. If lower doses of influenza vaccine can be identified that elicit a comparable protective response to standard doses, the vaccine supplies could be expanded to cover more individuals who are at risk of developing influenza.

The study involves individuals, ages 18 to 64, who are in good health. The participants will receive one to four doses of influenza vaccine. Study participants will make two study visits during a period of three weeks. Individuals who complete the study will be eligible to receive an approved 2005-06 flu vaccine as part of the study.

Individuals who are allergic to eggs or have had severe reactions to a flu vaccine should not participate. 

For more information, please call 319-384-7245 or 319-384-9569 between 8 a.m. and 5 p.m. Compensation is available.

UI Hospitals and Clinics is the state's only comprehensive academic medical center. University of Iowa Health Care describes the partnership between the UI Roy J. and Lucille A. Carver College of Medicine and UI Hospitals and Clinics and the patient care, medical education and research programs and services they provide. Visit UI Health Care online at http://www.uihealthcare.com.

STORY SOURCE: Joint Office for Marketing and Communications, University of Iowa Health Care, 200 Hawkins Drive, Room E110 GH, Iowa City, Iowa 52242-1009

MEDIA CONTACT: Tom Moore, 319-356-3945, thomas-moore@uiowa.edu.