University of Iowa News Release
April 7, 2005
UI Studying Non-Hormonal Medication For Women With Hot Flashes
The University of Iowa is taking part in a new international study of a non-hormonal medication for the treatment of hot flashes in postmenopausal women.
Many women experience hot flashes during and after menopause. Hot flashes are sudden sensations of heat that are particularly experienced in the head, neck, upper chest and back. Hot flashes may be accompanied by sweating, flashing, palpitations and anxiety, and they can occur anytime, day or night.
"The most used and effective treatment for hot flashes is hormone therapy in the form of estrogens alone or in combination with progestagens," said Susan Johnson, M.D., professor of obstetrics and gynecology in the UI Roy J. and Lucille A. Carver College of Medicine and director of the Menopause Clinic at UI Hospitals and Clinics. "However, hormonal therapy is not an acceptable treatment option for all women, and non-hormonal treatments are now being investigated as alternatives for the treatment of hot flashes. We hope that this research study will help to improve the management of hot flashes in postmenopausal women."
The study will compare four different doses of a non-hormonal investigational medication with a placebo (inactive pill) for the relief of hot flashes. This is the first global study to investigate the effectiveness of a new class of drugs called Serotonin 2 Blocker (S2B) for the treatment of hot flashes. Postmenopausal women experiencing hot flashes may be eligible to participate in this worldwide clinical research study.
A total of 900 women are being recruited for the study at clinical centers throughout Australia, Europe, North America, Central America and Latin America. Approximately 12 women will be enrolled at the UI. This is a 20-week study that will require six visits to the research clinic in Iowa City.
Patients may qualify for this study if they are:
--Between 40 and 65 years of age.
--Naturally postmenopausal (no menstrual bleeding for six months) or surgically postmenopausal (having had a hysterectomy with ovaries removed).
--Experiencing daily, frequent, moderate to severe hot flashes.
--Are willing to take three months of a non-hormonal medication or placebo (inactive pill).
All participants who qualify for the study will receive confidential medical examinations, blood tests and study medication.
Compensation is available for time and travel. For more information, call 319-384-5055 or toll free 800-348-4692.
University of Iowa Health Care describes the partnership between the UI Roy J. and Lucille A. Carver College of Medicine and UI Hospitals and Clinics and the patient care, medical education and research programs and services they provide. Visit UI Health Care online at http://www.uihealthcare.com.
STORY SOURCE: University of Iowa Health Science Relations, 5139 Westlawn, Iowa City, Iowa 52242-1178
MEDIA CONTACT: David Pedersen, (319) 335-8032, firstname.lastname@example.org.