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University of Iowa Health Care News Release

Sept. 2, 2003

UI Alzheimer's Study Seeks Participants

People ages 40 to 85 who have been diagnosed with mild to moderate dementia associated with Alzheimer's disease are invited to participate in a University of Iowa Health Care study. The investigation will determine the safety and effectiveness of different doses of a medication, compared to placebo (inactive pill), in treating symptoms such as forgetfulness, confusion, difficulty finding words or performing familiar tasks, and poor or impaired judgment.

Eligible participants must generally be healthy or have well-controlled medical conditions. In addition, women must be without childbearing potential. All participants must have a caregiver (relative or legally authorized representative) who is willing to participate in the consent process and other aspects of the study.

The investigation will last up to five months and involve up to 13 visits to UI Hospitals and Clinics in Iowa City. Visits will involve interviews and medical evaluations such as a physical exam and electrocardiogram (painless tracing of the electrical activity of the heart).

Eligible participants randomly will be assigned to take the placebo or one of three different doses of the study drug for 14 weeks. During the second part of the study, participants will not receive any placebo or medication for six weeks. All study-related medical evaluations and tablets will be provided at no cost to participants. Compensation for travel and parking is available.

Approximately 20 people will take part in the study at the UI. The investigation involves nearly 420 people at 70 sites in the United States and Canada. The UI portion of the study is led by Susan Schultz, M.D., UI associate professor of psychiatry.

For more information, call Jane Kerr in the UI Department of Psychiatry at 319-353-4955

University of Iowa Health Care describes the partnership between the UI Roy J. and Lucille A. Carver College of Medicine and UI Hospitals and Clinics and the patient care, medical education and research programs and services they provide. Visit UI Health Care online at www.uihealthcare.com.

STORY SOURCE: University of Iowa Health Science Relations, 5137 Westlawn, Iowa City, Iowa 52242-1178

CONTACTS: Study Participants: Jane Kerr, UI Department of Psychiatry, 319-353-4955 Media: Becky Soglin, Writer, 319-335-6660