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University of Iowa News Release

The following UI news release originally was distributed June 26, 2003. Participants still are welcome to the study through Feb. 6, 2004.

Nov. 13, 2003

UI Study On Aging Invites Participants

People ages 55 to 90 who have atherosclerosis (deposits of fatty substances or other material that narrow or block blood vessels) are invited to participate in a University of Iowa Health Care study. The purpose of the study is to better understand how blood vessel function relates to cognition, which is the ability to remember things, pay attention, learn and solve problems.

For possible eligibility, volunteers must have at least one of the following conditions: atherosclerosis (blockage of the blood vessels), claudication (peripheral vascular disease), angina, previous heart attack, angioplasty, or stent placement. Eligible participants must not have had a stroke or coronary artery bypass surgery.

The study will involve four visits to UI Hospitals and Clinics over the course of three years and phone contact approximately every three months throughout the study. Visits 1 and 2 will take place close together at the start of participants' entry into the study. Visits 3 and 4 will be held three years later, at the end of the study.

Visits 1 and 3 will involve an interview, health history, cognitive testing and physical examination. A small sample of blood will be drawn to measure blood fats, sugars, hormones and proteins. In addition, the blood samples taken at the first visit will be used as part of a DNA analysis to determine whether a particular gene is present that may be a risk factor for some forms of cognitive impairment.

During visits 2 and 4, participants will be given several medications to see how they affect blood vessel function over a three-hour period. In addition, at these visits participants will receive a 30-minute ultrasound (sonar) scan of the arm as another test of blood vessel function.

Compensation is available. Approximately 110 people will take part in the study, which is led by David Moser, Ph.D., assistant professor of psychiatry in the UI Roy J. and Lucille A. Carver College of Medicine. The five-year investigation is funded by a $778,000 grant from the National Institute on Aging.

For more information, call Becky Reese, UI research assistant in psychiatry, at 319-353-4276.

University of Iowa Health Care describes the partnership between the UI Roy J. and Lucille A. Carver College of Medicine and UI Hospitals and Clinics and the patient care, medical education and research programs and services they provide. Visit UI Health Care online at http://www.uihealthcare.com.

STORY SOURCE: University of Iowa Health Science Relations, 5137 Westlawn, Iowa City, Iowa 5224-1178

CONTACTS: Study Participants: Becky Reese (UI research assistant in psychiatry), 319-353-4276; Media: Becky Soglin, 319-335-6660, becky-soglin@uiowa.edu