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CONTACT: BECKY SOGLIN
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Iowa City IA 52242
(319) 335-6660; fax (319) 384-4638
e-mail: becky-soglin@uiowa.edu

Release: May 29, 2002

NOTE TO EDITORS: This release originally was distributed April 22, 2002. Participants still are welcome in the study until June 21, 2002.

People with type 2 diabetes invited to participate in medication study

People who have had type 2 diabetes for one year or longer are invited to participate in a University of Iowa Health Care study of specific drug combinations to control blood sugar. The study will last approximately seven months.

Eligible participants must be ages 18 to 79 and currently taking only metformin (Glucophage) and a sulfonylurea (Amaryl, Diabeta, Micronase, Glyburide, Glynase or Glucatrol). Participants must be willing to give themselves an injection once a day. In addition, women must not be pregnant, breastfeeding or planning to conceive while enrolled in the study.

The study will focus on comparing how well a once daily injection of either Lantus or Humalog mix 75/25 improves blood sugar control when either of them is added to drug treatment that already includes Glucophage and a sulfonylurea.

Potential participants will make an initial screening visit to determine eligibility. If a person is found eligible, participation in the study will require six additional visits over an approximately 24-week period to UI Hospitals and Clinics. At the second visit, participants will randomly be assigned to take one of the two study medications, along with their other diabetes medication, forthe remainder of the study period.

Participation will involve fasting blood tests, EKG exams (heart tracing), physical exams, dietary and exercise instructions, and daily home blood sugar monitoring with recording of readings in a diary.

Diabetes medication, a blood glucose monitor and necessary supplies, as well as compensation for travel and participation, will be provided. In addition, all tests and examinations related to the study will be free of charge. The study is being led by Udaya Kabadi, M.D., UI professor of internal medicine. The UI is one of 35 centers nationwide participating in the study.

For more information, contact Sheila Wayson, study coordinator, toll-free at (877) 807-9590 or locally at 356-4879 or by e-mail at sheila-wayson@uiowa.edu.

University of Iowa Health Care describes the partnership between the UI Roy J. and Lucille A. Carver College of Medicine and the UI Hospitals and Clinics and the patient care, medical education and research programs and services they provide. Visit UI Health Care online at http://www.uihealthcare.com/.