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CONTACT: DAVE PEDERSEN
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Iowa City IA 52242
(319) 335-8032; fax (319) 384-4638
e-mail: david-pedersen@uiowa.edu

Release: Jan. 28, 2002

Women invited to participate in UI hormone replacement therapy study

IOWA CITY, Iowa -- The University of Iowa College of Public Health is beginning a new, 28-week research study comparing two forms of hormone replacement therapy that are currently available by prescription. Women, ages 40 to 65, who have gone at least six months since their last menstrual period are invited to participate.

To qualify, women must have their uterus present and must not be currently taking any kind of hormone replacement therapy. Participants in the UI study will be asked to make five visits to the study clinic in Iowa City. All study participants will receive one of the two active study medications being tested. There will be no placebo (inactive pill) given in this study. Testing such as mammograms, Pap and pelvic exams, and a physical exam will be provided free of charge. Compensation is available.

"Hormone replacement therapy is currently prescribed for the treatment of hot flashes, other symptoms associated with menopause and the prevention of osteoporosis," said Helmut Schrott, M.D., UI professor of epidemiology and principal investigator for the study.

However, according to Schrott, hormone replacement therapy use among women overall is low because of the side effects. "If side effects can be reduced, women might be more able to stay on this type of therapy," he said.

One of the most common side effects of hormone replacement therapy is unwanted vaginal bleeding or spotting. The UI study will compare the two types of hormone replacement therapy for incidences of bleeding or spotting.

For more information about this research study, call (319) 384-5055 or toll-free (800) 348-4692.