CONTACT: BECKY SOGLIN
Iowa City IA 52242
(319) 335-6660; fax (319) 335-8034
Release: Sept. 6, 2000
[NOTE TO EDITORS: This call for participants is a re-release of a news release
first distributed in January. Participants are still needed for the study.]
UI invites people with mild thyroid failure to take part in cholesterol
IOWA CITY, Iowa -- University of Iowa Health Care researchers invite people
with mild thyroid failure to participate in a study of the safety and effectiveness
of Synthroid in reducing low density lipoprotein (LDL) cholesterol.
Participants must be aged 35 to 75 and willing to make approximately 14
visits to the UI Hospitals and Clinics over the 12-month study period. Prospective
participants must not be receiving thyroid hormone replacement therapy or,
with physician supervision, must be able to discontinue thyroid hormone replacement
therapy. Women must not be pregnant or planning to conceive while enrolled
in the study. Compensation is available, and all medication, tests and examinations
will be provided free of charge.
People with mild thyroid failure may experience symptoms such as depression,
fatigue, dry skin, brittle nails, inability to concentrate, loss of appetite,
muscle cramps, weight gain and hoarseness. Women with the condition may have
The study is a double-blinded trial for the first six months. Participants
will receive either the Synthroid or a placebo but neither the participants
nor the investigators will know who is receiving which medication. During
the remaining six months, all participants will receive only the Synthroid.
For more information, call Sheila Wayson, nurse clinician and trial coordinator,
toll-free at (877) 807-9590 or locally at (319) 356-4879 and ask about the
thyroid / LDL study.
LDL cholesterol is known as the "bad" cholesterol component in
blood, while high density lipoprotein (HDL) cholesterol is known as the "good"
component. High LDL levels in blood have been associated with increased risk
of heart problems.
When the thyroid level falls, LDL cholesterol can become elevated, said
Udaya M. Kabadi, M.D., UI associate professor (clinical) of internal medicine
and the study's lead investigator.
"In addition to studying whether Synthroid can reduce LDL cholesterol
in people with mild thyroid failure, we will also investigate whether the
drug affects the distribution of LDL and HDL cholesterol and how the therapy
affects patients' quality of life," said Kabadi, who is also a staff
physician at the Veterans Affairs Medical Center in Iowa City.
Mild thyroid failure affects an estimated 7 to 17 percent of women and 2
to 14 percent of men in the United States. The disease is characterized by
elevated blood thyroid-stimulating hormone (TSH) concentration. In normal
conditions, the pituitary gland produces this hormone, which then stimulates
the thyroid gland to produce thyroid hormones. However, in people with mild
thyroid failure, the pituitary gland puts out excessive TSH in an effort to
stimulate an underfunctioning thyroid gland.
University of Iowa Health Care describes the partnership between
the UI College of Medicine and the UI Hospitals and Clinics and the patient
care, medical education and research programs and services they provide.