CONTACT: ZLATKO ANGUELOV
8788 John Pappajohn Pavilion
Iowa City IA 52242
Release: Aug. 11, 2000
UI Hospitals and Clinics enrolls patients in clinical trial on hypothermia
for aneurysm surgery
IOWA CITY, Iowa -- The University of Iowa Hospitals and Clinics is enrolling
patients with ruptured aneurysms who may qualify to participate in a large,
international, multicenter, prospective, randomized, partially blind clinical
trial designed to evaluate whether hypothermia significantly improves long-term
neurological outcome in patients undergoing open brain surgery for aneurysm
An aneurysm is an abnormally dilated portion of an artery within the brain.
As the aneurysm expands it may rupture into an area surrounding the brain
termed the subarachnoid space. Aneurysmal subarachnoidal hemorrhage occurs
in more than 30,000 people per year in North America.
"This trial was designed after a pilot study demonstrated that hypothermia
may be beneficial for patients operated on for ruptured aneurysms," said
Mazen Maktabi, M.D., UI associate professor of anesthesia and principal investigator
for the UI Hospitals and Clinics part of the trial. "Now we want to see
if hypothermia really helps reduce neural injury following aneurysm clipping."
"Ruptured aneurysms are emergency cases for brain surgery," said
the trial's lead neurosurgeon Vincent Traynelis, M.D., UI professor of surgery.
"That's why we want community physicians who first see such patients
to be aware of the ongoing trial to assure timely referral of appropriate
Aneurysmal hemorrhage causes stroke of varied severity, but aneurysmal surgery
places patients at risk for further injury. The trial is based on the hypothesis
that mild reduction of body temperature to 33°C during surgery can prevent
additional injuries to the brain.
Nine hundred patients worldwide will be recruited before the trial's results
can be processed and analyzed. Since the beginning of the trial in March 2000,
the UI Hospitals and Clinics trial center has enrolled 12 patients, the greatest
number among all U.S. trial centers to date.
University of Iowa Health Care describes the partnership between the
UI College of Medicine and the UI Hospitals and Clinics and the patient care,
medical education and research programs and services they provide.