CONTACT: BECKY SOGLIN
2130 Medical Laboratories
Iowa City IA 52242
(319) 335-6660; fax (319) 335-8034
Release: Nov. 9, 1999
UI invites people to take part in sickle cell disease study
IOWA CITY, Iowa -- University of Iowa Health Care researchers invite
people with sickle cell disease to participate in a study of the effectiveness
of Cordox, an experimental sugar-based therapy, in helping treat acute pain
Participants must be 15 years or older and have experienced associated
painful events that require hospitalization. Women must not be pregnant or
planning to conceive within 30 days of trial participation. Each individual
must be willing to make one visit to the UI Hospitals and Clinics during a
painful sickle cell episode and remain there for at least three days after
receiving standard narcotic treatment and either the study drug or a placebo.
Sickle cell crises occur when red blood cells change shape, known as
sickling. The sickling clogs blood vessels and prevents oxygen from reaching
tissues, causing intense pain, infection and other problems. Cordox is reported
to increase the energy content of red blood cells and decrease sickling.
The UI is one of several centers nationwide participating in the trial.
The UI portion of the study is led by co-investigators Thomas W. Loew, M.D.,
assistant professor (clinical) of pediatrics, and Raymond L. Hohl, M.D., Ph.D.,
associate professor of internal medicine and pharmacology, and division director
of hematology-oncology, blood and marrow transplantation.
"We want to investigate how well the drug is tolerated by patients during
sickle cell painful events and how effective the treatment is," Loew said.
"The study is also designed to determine the lowest dose of Cordox that can
be used to alleviate pain."
He added, "Painful crises are the most common side effect of sickle cell
disease. If we can manage these crises better, we will go a long way in helping
patients with this life-long disease."
For more information, call Penny Grafton, nurse coordinator for the UI
Hemoglobinopathy Program, at (319) 356-1400.
University of Iowa Health Care describes the partnership between the
UI College of Medicine and the UI Hospitals and Clinics and the patient care,
medical education and research programs and services they provide.