CONTACT: JENNIFER CRONIN
2130 Medical Laboratories
Iowa City IA 52242
(319) 335-9917; fax (319) 335-8034
Release: Dec. 14, 1999
UI researcher receives $1.2 million grant from the National Institutes
IOWA CITY, Iowa University of Iowa Health Care researcher Andrew
Russo, Ph.D., associate professor of physiology and biophysics, has received
a five-year, $1.2 million grant from the National Institutes of Health to
continue his investigation of a compound associated with migraines and stroke.
Russo and investigators in his laboratory will use the funding to learn more
about how the body regulates a neuropeptide known as the calcitonin gene-related
peptide (CGRP). The peptide compound is involved in several neurovascular
disorders, most notably migraines and subarachnoid hemorrhage, a type of stroke.
"Despite its importance in physiological and disease states, the regulation
of CGRP production is not well understood," Russo said.
The Russo investigative team will study the roles that nerves play in controlling
CGRP production. The researchers also plan to look at how inflammatory agents
involved in migraine and stroke affect the levels of the neuropeptide in model
"We hope to identify the signal transduction pathways and transcription
factors that are important for controlling CGRP neuropeptide gene expression
in neurons," Russo said. "This information will potentially provide
new targets for therapeutic strategies designed to regulate and control CGRP
levels and potentially provide insight into migraines and stroke."
University of Iowa Health Care describes the partnership between the UI College
of Medicine and the UI Hospitals and Clinics and the patient care, medical
education and research programs and services they provide.